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THYROID FUNCTION TEST (T3 T4 TSH) / THYROID PROFILE


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THYROID FUNCTION TEST (T3 T4 TSH) / THYROID PROFILE


Thyroid is a butterfly shaped gland located in the neck of humans. It produces two hormones - T3 and T4 which regulate multiple functions of the body including metabolism, energy generation and mood control. If the thyroid gland does not produce the right amount of T3, T4 hormones, conditions called hypothyroidism (low levels of hormones) or hyperthyroidism (high level of hormones) may occur. Women are 10 times more likely than men to suffer from thyroid disorders.

Thyroid Function Test (T3, T4, TSH) or Thyroid Profile Test is ordered in patients who manifest either symptom of hypothyroidism or hyperthyroidism


Hyperthyroidism


If excessive hormones are produced, then a person may lose weight, have tremors or feel anxious. This condition is called hyperthyroidism.

Symptoms of hyperthyroidism:
  • Fatigue or muscle weakness.
  • Hand tremors.
  • Mood swings.
  • Nervousness or anxiety.
  • Rapid heartbeat.
  • Heart palpitations or irregular heartbeat.
  • Skin dryness.
  • Trouble sleeping
Symptoms
						of hyperthyroidism

Hypothyroidism


If the thyroid gland does not produce enough levels of T3 and T4, a condition called hypothyroidism, a person may experience weight gain, lack of energy, depressive mood, dry skin and some other ailments. 2% of population suffer from hypothyroidism.


Symptoms of Hypothyroidism
  • Fatigue.
  • Weakness.
  • Weight gain or increased difficulty losing weight.
  • Coarse, dry hair.
  • Dry, rough pale skin.
  • Hair loss.
  • Cold intolerance (you can't tolerate cold temperatures like those around you)
  • Muscle cramps and frequent muscle aches.
Symptoms
						of hyperthyroidism

WHAT IS BEING TESTED IN THYROID PROFILE


  • TSH- Thyroid stimulating Hormone
  • T4- Thyroxine ( produced by thyroid )
  • T3- Triiodothyronine ( produced by thyroid )

Free forms of T4 and T3 are also measures as FT4, FT3


INTERPRETATION OF THYROID PROFILE TEST RESULT


Disease /Condition TSH FT4 T4 FT3 T3

Euthyroid

N N N N N

Subclinical Hypothyroidism

H N N N N

Hypothyroid

H N L N/L N/L

Subclinical Hyperthyroidism

L L N N N

Hyperthyroid

L H H H H

Pregnancy (high TBG)

N N H N H

T3 Thyrotoxicosis

L N/L N/L H H

Note: N = normal; L = low; H = high;


REFERENCE RANGE FOR THYROID FUNCTION TEST


Typical reference ranges for normal thyroids.


Test From To Units
TSH 0.4 4.5

mU/L (milliunits per litre)

FT4 9.0 25.0

pmol/L (picomoles per litre)

FT3 3.5 7.8

pmol/L (picomoles per litre)


For more information on Thyroid Function Test, Thyroid Stimulating Hormones, Hyperthyroidism or Hypothyroidism check out other resources:



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