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Activated Partial Thromboplastin Time/ APTT/PTT K/ Partial Thromboplastin Time

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REASON FOR TESTING OF APTT/PTT


APTT/PTT can be ordered along with PT - INR in following conditions antSicoagulant. It is also ordered in patients who show symptoms of bleeding disorders like -

  • Bleeding gums
  • Nose bleed
  • Easy bruising
  • Disseminated Intravascular coagulation ( DIC )
  • Chronic liver disease
  • Pre surgery evaluation

WHAT IS BEING TESTED IN APTT/PTT


The APTT is functional determination of the intrinsic pathway of coagulation. (Factors XII, XI, IX, VIII, V, II, I, prekallikrein, high molecular weight kininogen).


INTERPRETATION OF APTT/PTT TEST RESULT


Prolonged in - Haemophilia A or B

Factor XI deficiency
von Willebrand disease
factor XII deficiency
Disseminated Intravascular coagulation

APTT/PTT REFERENCE RANGE


30-40 seconds


APTT/PTT RELATED TESTS


Additional test- ordered along with APTT to follow the abnormal results.

PT - determine the functional activity of extrinsic factors of coagulation pathway.( link PT )

Platelet count - low platelet count predispose to bleeding. (link platelet count )

Fibrinogen test - low fibrinogen level predispose to bleeding.

Von Willebrand factor - to rule out von Willebrand disease.

Coagulation factors - factor levels provide in depth analysis of the cause of prolonged PT.

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